(R)-MG132 Laboratory Chemical

Product Description

DESCRIPTION

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression.1,2 (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.3 The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 M (ChTL); 34.4 versus 104.43 M (TL); 2.95 versus 5.70 M (PGPH), respectively).3

TECHNICAL INFORMATION

Formal Name

N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-formyl-3-methylbutyl]-L-leucinamide

CAS Number

1211877-36-9

Molecular Formula

C26H41N3O5

Formula Weight

475.6

Purity

98%

Formulation

A crystalline solid

SHIPPING & STORAGE

-20C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

2 years