AFP 07 (free acid)

Product Description

DESCRIPTION

Prostaglandin I2 is an unstable prostanoid which, through the I prostanoid (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values of > 100 nM for EP1-3 and > 10 nM for EP4.1 In piglet and rabbit saphenous veins, which express both IP and EP4, the EP4 antagonist AH 23848 reduces AFP 07-mediated relaxation, suggesting that AFP 07 activates EP4 as well as IP, particularly when both receptors are present.2

TECHNICAL INFORMATION

Formal Name

5Z-[(3aR,4R,5R,6aS)-3,3-difluorohexahydro-5-hydroxy-4-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2H-cyclopenta[b]furan-2-ylidene]-pentanoic acid

CAS Number

788799-13-3

Molecular Formula

C22H30F2O5

Formula Weight

412.5

Purity

98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

-20^oC

Shipping

Wet ice in continental US; may vary elsewhere

Stability

1 year