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            Home » Products » Bromodomain Inhibitor, (+)-JQ1

            Bromodomain Inhibitor, (+)-JQ1

            Bromodomain Inhibitor, (+)-JQ1
            Bromodomain Inhibitor, (+)-JQ1
            Product Code : 31
            Product Description

            CAS Number : 1268524-69-1

            Empirical Formula (Hill Notation) :  C23H25ClN4O2S

            Molecular Weight : 456.99 

            MDL number : MFCD23726614


            Other Notes

            Racemic mixture

            Biochem/physiol Actions

            The human BET family, which includes BRD2, BRD3, BRD4 and BRDT, play a role in regulation of gene transcription. (+/-)-JQ1 ((+/-)SGCBD01) is a selective BET bromodomain (BRD) inhibitor that inhibits Brd4 (Bromodomain-containing 4). Brd4 forms complexes with chromatin via two tandem bromodomains (BD1 and BD2) that bind to acetylated lysine residues in histones and Brd4 association with acetylated chromatin is believed to regulate the recruitment of elongation factor b and additional transcription factors to specific promoter regions. The nuclear protein in testis (NUT) gene is known to form fusions with Brd4 that create a potent oncogene, leading to rare, but highly lethal tumors referred to as NUT midline carcinomas (NMC). JQ1 inhibits recruitment and binding of Brd4 to TNFα and E-selectin promoter elements, and accelerates recovery time in FRAP (fluorescence recovery after photobleaching) assays using GFP-Brd4. Thus JQ1/SGCBD01 is a useful tool to study the role of Brd4 in transcriptional initiation. For full characterization details, please visit the SGCBD01/JQ1 probe summary on the Structural Genomics Consortium (SGC) website.

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