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                          Home » Products » DAPT (GSI-IX)

                          DAPT (GSI-IX)

                          DAPT (GSI-IX)
                          DAPT (GSI-IX)
                          Product Code : 36
                          Product Description

                          CAS Number : 208255-80-5

                          Empirical Formula (Hill Notation) : C23H26F2N2O4

                          Molecular Weight : 432.46 

                          MDL number : MFCD04974585

                          PubChem Substance ID 24893987 


                          25 mg in poly bottle

                          5 mg in glass bottle

                          Biochem/physiol Actions

                          DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE), as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells (hIPSC).


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