Product Description
Synonyms
The amino acid aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC and a G protein-coupled receptor, GABAB. Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA on both high-and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM.1 enhance the effects of muscimol via GABAA without altering its binding.1,2 Muscimol activates GABAC receptors with an EC50 value of 1.3 M.3 It also acts as an inhibitor of GABAA uptake and a substrate for the GABA-metabolizing enzyme GABA transaminase.4 Muscimol impairs memory formation and retrieval in mice and attenuates airway constriction in guinea pigs in vivo.5,6
TECHNICAL INFORMATION
Formal Name
5-(aminomethyl)-3(2H)-isoxazolone
CAS Number
2763-96-4
Synonyms
Molecular Formula: C4H6N2O2
Formula Weight: 114.1
Purity: 98%
Formulation: A crystalline solid
SHIPPING & STORAGE
Storage: -20 °C
Shipping: Room temperature in continental US; may vary elsewhere
Stability: 2 years