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UNC0224

UNC0224

3800-77000 INR

Product Details:

  • Boiling point REFER C.O.A MSDS
  • Usage R&D FORMULATION
  • Shape Crystal
  • HS Code 3821
  • Taste Bitter
  • Smell Stimulus
  • Molecular Formula C26H43N7O2
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UNC0224 Price And Quantity

  • 3800.00 - 7700.00 INR
  • 3800-77000 INR
  • 1 Pack

UNC0224 Product Specifications

  • Crystal
  • POWDER
  • WHITE
  • R&D FORMULATION
  • REFER C.O.A MSDS
  • Other
  • 1197196-48-7
  • Bitter
  • C26H43N7O2
  • 3821
  • TETRA HYDROXI STEAROL
  • 485.7 Kilograms (kg)
  • Stimulus
  • 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
  • Solid
  • REFER C.O.A MSDS
  • High Purity
  • C26H43N7O2
  • REFER C.O.A MSDS
  • 98%
  • 24 Months

UNC0224 Trade Information

  • Days after Acceptance (DA) Cash Advance (CA) Cheque
  • 10 Pack Per Day
  • 10-15 Days
  • Yes
  • Within a certain price range free samples are available
  • 1MG 5MG 10MG 50MG
  • Asia
  • All India

Product Description

DESCRIPTION

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.1,2,3 UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM.4 Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase).4

TECHNICAL INFORMATION

Formal Name

7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine

CAS Number

1197196-48-7

Molecular Formula

C26H43N7O2

Formula Weight

485.7

Purity

98%

Formulation

A crystalline solid

max

251, 346 nm

SHIPPING & STORAGE

Storage

 

-20oC

Shipping

Room temperature in continental US; may vary elsewhere

Stability

2 years

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