Wortmannin-Rapamycin Conjugate

12400-99200 INR

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Product Details:

Molecular Weight 1598.9 Kilograms (kg)
Taste Bitter
Other Names 1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate
Shape Crystal
Physical Form Powder
Structural Formula C88H131N3O23
HS Code 3821
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Wortmannin-Rapamycin Conjugate Price And Quantity

Minimum Order Quantity 1 Pack
Price Range 12400.00 - 99200.00 INR
Price 12400-99200 INR

Wortmannin-Rapamycin Conjugate Product Specifications

Smell Stimulus
Molecular Weight 1598.9 Kilograms (kg)
Color WHITE
Shelf Life 24 Months
HS Code 3821
Structural Formula C88H131N3O23
Chemical Name Other
Type TETRA HYDROXI STEAROL
Ph Level REFER C.O.A MSDS
Usage R&D FORMULATION
Appearance POWDER
Taste Bitter
Boiling point REFER C.O.A MSDS
Purity(%) 98%
Physical Form Powder
Melting Point REFER C.O.A MSDS
Classification High Purity
Shape Crystal
Other Names 1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate
Molecular Formula C88H131N3O23
CAS No 1067892-47-0

Wortmannin-Rapamycin Conjugate Trade Information

Payment Terms Days after Acceptance (DA) Cheque Cash Advance (CA)
Supply Ability 10 Pack Per Day
Delivery Time 10-15 Days
Sample Available Yes
Sample Policy Within a certain price range free samples are available
Packaging Details 500 g 1 MG 5MG
Main Export Market(s) Asia
Main Domestic Market All India

Product Description

DESCRIPTION

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1.1,2 Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker.3 Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone.3 Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.3

TECHNICAL INFORMATION

Formal Name

1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate

CAS Number

1067892-47-0

Molecular Formula

C88H131N3O23

Formula Weight

1598.9

Purity

98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

-20C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

2 years

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