ZK118182 isopropyl ester

16900-76100 INR

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Product Details:

Appearance POWDER
Other Names [[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester
Physical Form Powder
Ph Level REFER C.O.A MSDS
Usage R&D FORMULATION
Smell Stimulus
Shelf Life 12 Months
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ZK118182 isopropyl ester Price And Quantity

Minimum Order Quantity 1 Pack
Price Range 16900.00 - 76100.00 INR
Price 16900-76100 INR

ZK118182 isopropyl ester Product Specifications

Boiling point REFER C.O.A MSDS
Density Kilogram per cubic meter (kg/m3)
Purity(%) 98%
Taste Bitter
Shape Crystal
HS Code 3821
Molecular Formula C23H37ClO5
Molecular Weight 429.0 Kilograms (kg)
Melting Point REFER C.O.A MSDS
Color WHITE
CAS No 154927-31-8
Type TETRA HYDROXI STEAROL
Physical Form Powder
Ph Level REFER C.O.A MSDS
Chemical Name Other
Other Names [[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester
Appearance POWDER
Classification High Purity
Structural Formula C23H37ClO5
Shelf Life 12 Months
Usage R&D FORMULATION
Smell Stimulus

ZK118182 isopropyl ester Trade Information

Payment Terms Cash Advance (CA) Days after Acceptance (DA) Cheque
Supply Ability 10 Pack Per Day
Delivery Time 10-15 Days
Sample Available Yes
Sample Policy Within a certain price range free samples are available
Packaging Details 100 g 500 g
Main Export Market(s) Asia
Main Domestic Market All India

Product Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2 and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50Â = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki= 74 nM).1Â ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03g , ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.2

TECHNICAL INFORMATION

Formal Name

[[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester

CAS Number

154927-31-8

Molecular Formula

C23H37ClO5

Formula Weight

429.0

Purity

98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

Storage

-20^oC

Shipping

Room temperature in continental US; may vary elsewhere

Stability

1 year

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