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(R)-MG132 Laboratory Chemical

(R)-MG132 Laboratory Chemical

4300-75300 INR

Product Details:

  • Taste Bitter
  • Structural Formula C26H41N3O5
  • HS Code 3821
  • Boiling point REFER C.O.A MSDS
  • Usage R&D FORMATION
  • Physical Form Powder
  • Shelf Life 24 Months
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(R)-MG132 Laboratory Chemical Price And Quantity

  • 1 Pack
  • 4300-75300 INR

(R)-MG132 Laboratory Chemical Product Specifications

  • REFER C.O.A MSDS
  • REFER C.O.A MSDS
  • REFER C.O.A MSDS
  • Stimulus
  • N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-formyl-3-methylbutyl]-L-leucinamide
  • 98%
  • 475.6 Kilograms (kg)
  • Crystal
  • Other
  • POWDER
  • C26H41N3O5
  • TETRA HYDROXI STEAROL
  • 24 Months
  • High Purity
  • 1211877-36-9
  • R&D FORMATION
  • 3821
  • WHITE
  • Powder
  • Bitter
  • C26H41N3O5

(R)-MG132 Laboratory Chemical Trade Information

  • Days after Acceptance (DA) Cheque Cash Advance (CA)
  • 10 Pack Per Day
  • 10-15 Days
  • Yes
  • Within a certain price range free samples are available
  • 1MG 5MG 10MG 25MG
  • Asia
  • All India

Product Description

DESCRIPTION

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression.1,2 (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.3 The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 M (ChTL); 34.4 versus 104.43 M (TL); 2.95 versus 5.70 M (PGPH), respectively).3

TECHNICAL INFORMATION

Formal Name

N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-formyl-3-methylbutyl]-L-leucinamide

CAS Number

1211877-36-9

Molecular Formula

C26H41N3O5

Formula Weight

475.6

Purity

98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

 

-20C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

2 years

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