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(R)-MG132

(R)-MG132
(R)-MG132
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Product Code : SRGCC29
Brand Name : S.R GROUP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price Range
  • 4300.00 - 75300.00 INR
  • Price
  • 4300-75300 INR
Product Specifications
  • HS Code
  • 3821
  • Structural Formula
  • C26H41N3O5
  • Shape
  • Crystal
  • Melting Point
  • REFER C.O.A MSDS
  • Other Names
  • N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-formyl-3-methylbutyl]-L-leucinamide
  • Appearance
  • POWDER
  • Taste
  • Bitter
  • Shelf Life
  • 24 Months
  • Molecular Formula
  • C26H41N3O5
  • Smell
  • Stimulus
  • Density
  • REFER C.O.A MSDS
  • Physical Form
  • Powder
  • Boiling point
  • REFER C.O.A MSDS
  • Ph Level
  • REFER C.O.A MSDS
  • Molecular Weight
  • 475.6 Kilograms (kg)
  • Usage
  • R&D FORMATION
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 1211877-36-9
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression.1,2 (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.3 The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 µM (ChTL); 34.4 versus 104.43 µM (TL); 2.95 versus 5.70 µM (PGPH), respectively).3

TECHNICAL INFORMATION

Formal Name

N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-formyl-3-methylbutyl]-L-leucinamide

CAS Number

1211877-36-9

Molecular Formula

C26H41N3O5

Formula Weight

475.6

Purity

≥98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years

Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 1MG 5MG 10MG 25MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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