LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent.1,2Â (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer.2Â When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation.3Â Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.
A crystalline solid
SHIPPING & STORAGE
Room temperatureÂ in continental US; may vary elsewhere
Ã¢ÂÂ¥ 2 years