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ABT-869

ABT-869
ABT-869
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Product Code : SRGCC55
Brand Name : S.R GROUP CHEMICAL
Price And Quantity
  • Minimum Order Quantity
  • 1 Pack/Packs
  • Price Range
  • 4900.00 - 15900.00 INR
  • Price
  • 4900-15900 INR
Product Specifications
  • HS Code
  • 3821
  • Shape
  • Crystal
  • Taste
  • Bitter
  • Ph Level
  • REFER C.O.A MSDS
  • Melting Point
  • REFER C.O.A MSDS
  • Physical Form
  • Solid
  • Other Names
  • N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N’-(2-fluoro-5-methylphenyl)-urea
  • Structural Formula
  • C21H18FN5O
  • Usage
  • R&D FORMULATION
  • Molecular Weight
  • 375.4 Kilograms (kg)
  • Shelf Life
  • 12 Months
  • Density
  • REFER C.O.A MSDS Kilogram per cubic meter (kg/m3)
  • Smell
  • Stimulus
  • Molecular Formula
  • C21H18FN5O
  • Boiling point
  • REFER C.O.A MSDS
  • Appearance
  • POWDER
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 796967-16-3
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

Synonyms

  • Linifanib

Receptor tyrosine kinases (RTKs) mediate critical signaling transduction pathways important for cell survival, growth, and differentiation. Whereas aberrant tyrosine kinase signaling is correlated with the progression of various cancers, RTK inhibitors are useful as cancer therapy agents. ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families (e.g., KDR, FLT1, FLT3, FLT4, CSF-1R, and KIT) demonstrating IC50 values ranging from 4-190 nM.1 ABT-869 shows little activity against unrelated RTKs, cytoplasmic tyrosine kinases, or Ser/Thr kinases (IC50s > 1 M).1 ABT-869 inhibits proliferation in MV-4-11 and MOLM-13 cells (acute myeloid leukemia cell lines harboring RTK mutations; IC50s = 4 and 6 nM, respectively), inducing apoptosis as evidenced by an increased sub-G0/G1 phase cell population, caspase activation, and PARP cleavage.2 In murine xenograft models, as well as in a phase 1 clinical trial, ABT-869 demonstrated respectable efficacy in solid tumors including lung and hepatocellular carcinomas.3

TECHNICAL INFORMATION

Formal Name

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N-(2-fluoro-5-methylphenyl)-urea

CAS Number

796967-16-3

Synonyms

  • Linifanib

 

Molecular Formula

C21H18FN5O

Formula Weight

375.4

Purity

98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

 

-20oC

Shipping

Wet ice in continental US; may vary elsewhere

Stability

1 year

Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 1MG 5MG 10MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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