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Adapalene

Adapalene
Adapalene
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Product Code : SRGCC54
Brand Name : S.R GROUP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price
  • 13800-110400 INR
  • Price Range
  • 13800.00 - 110400.00 INR
Product Specifications
  • Molecular Formula
  • C28H28O3
  • Appearance
  • POWDER
  • Shelf Life
  • 24 Months
  • Structural Formula
  • C28H28O3
  • Physical Form
  • Solid
  • Molecular Weight
  • 412.5 Kilograms (kg)
  • Smell
  • Stimulus
  • Other Names
  • 6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
  • Usage
  • R&D FORMULATION
  • Melting Point
  • REFER C.O.A MSDS
  • Ph Level
  • REFER C.O.A MSDS
  • HS Code
  • 3821
  • Density
  • REFER C.O.A MSDS Milligram per cubic meter (mg/m3)
  • Boiling point
  • REFER C.O.A MSDS
  • Taste
  • Bitter
  • Shape
  • Crystal
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 106685-40-9
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

Synonyms

  • CD 271

Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RAR+, RAR, and RAR, respectively).1,2,3,4,5 It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 M) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).2 It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.3 It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.2 Adapalene (100 M) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.5,4 Formulations containing adapalene have been used in the treatment of acne vulgaris.

TECHNICAL INFORMATION

Formal Name

6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid

CAS Number

106685-40-9

Synonyms

  • CD 271

 

Molecular Formula

C28H28O3

Formula Weight

412.5

Purity

98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

 

-20oC

Shipping

Room temperature in continental US; may vary elsewhere

Stability

2 years

Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 100MG 250MG 500MG 1GM
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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