DESCRIPTION
Synonyms
Alfuzosin is a post-synaptic +1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).1,2 It displays high-affinity with non-selectivity for the three known human +1 adrenoceptors (pK = 8.0, 8.0, and 8.5 for +1A, +1B, and +1D, respectively).3 Consistent with a role for Ãޱ1 adrenoceptors in mediating contraction of smooth muscle, alfuzosin was first described as having anti-hypertensive effects with peripheral vasodilator properties.1 In patients with BPH, alfuzosin increases mean urinary flow rate and decreases residual volume.2 Alfuzosin produces minimal vasodilatory and sexual function side effects.4,5,6
TECHNICAL INFORMATION
Formal Name
N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide, monohydrochloride
CAS Number
81403-68-1
Synonyms
Molecular Formula
C19H27N5O4 HCl
Formula Weight
425.9
Purity
98%
Formulation
A crystalline solid
SHIPPING & STORAGE
Storage
-20oC
Shipping
Room temperature in continental US; may vary elsewhere
Stability
2 years