DESCRIPTION
The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism.1 AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3KÃŽ³ (IC50 = 70 nM), compared to PI3KÃŽ± (IC50 = 240 nM), PI3KÃŽ² (IC50 = 1.45 ÃŽ¼M), and PI3KÃŽ´ (IC50 =1.70 ÃŽ¼M).2 When tested at 1.0 ÃŽ¼M, it shows little or no activity against 38 other common kinases.2 When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.2
TECHNICAL INFORMATION
Formal Name
5-(1,3-benzodioxol-5-ylmethylene)-2,4-thiazolidinedione
CAS Number
6318-41-8
Molecular Formula
C11H7NO4S
Formula Weight
249.2
Purity
≥98%
Formulation
A crystalline solid
SHIPPING & STORAGE
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years