AS-041164 Chemical

DESCRIPTION

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism.1 AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3KÃŽ³ (IC50 = 70 nM), compared to PI3KÃŽ± (IC50 = 240 nM), PI3KÃŽ² (IC50 = 1.45 ÃŽ¼M), and PI3KÃŽ´ (IC50 =1.70 ÃŽ¼M).2 When tested at 1.0 ÃŽ¼M, it shows little or no activity against 38 other common kinases.2 When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.2

TECHNICAL INFORMATION

Formal Name

5-(1,3-benzodioxol-5-ylmethylene)-2,4-thiazolidinedione

CAS Number

6318-41-8

Molecular Formula

C11H7NO4S

Formula Weight

249.2

Purity

≥98%

Formulation

A crystalline solid

SHIPPING & STORAGE

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years