DESCRIPTION
Synonyms
Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFR (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively).1 Through its effects on VEGFRs, it causes regression of fenestrated, VEGFR-rich capillaries in tumors and normal tissue of mice, which is reversed following removal of the inhibitor.2,3,4 Axitinib has shown promise as a therapeutic in certain cancers and cancer models.5,6
TECHNICAL INFORMATION
SR GROUP
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