DESCRIPTION
Synonyms
AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50 = 0.36 nM).1 AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3Â AZD 1152 inhibits tumor xenograft growth in vivo.4,5
TECHNICAL INFORMATION
Formal Name
5-
CAS Number
722543-31-9
Synonyms
Molecular Formula
C26H31FN7O6P
Formula Weight
587.5
Purity
95%
Formulation
A crystalline solid
SHIPPING & STORAGE
-20oC
Shipping
Room temperature in continental US; may vary elsewhere
Stability
2 years
SR GROUP
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