CAY10408 Chemical

DESCRIPTION

Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, TP, FP, or IP receptors.1 CAY10408 is a free acid, 2-series analog of butaprost. It is the less active C-16 epimer compared to the 16(S) isomer, which has the same stereochemistry as butaprost. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.2 Since the majority of reports related to butaprost utilize the methyl ester derivative,3,4 it may be some time before the precise pharmacology of the free acid compounds, like CAY10408, is reported.

TECHNICAL INFORMATION

Formal Name

9-oxo-11ÃŽ±,16R-dihydroxy-17-cyclobutyl-5Z,13E-dien-1-oic acid

CAS Number

212310-16-2

Molecular Formula

C23H36O5

Formula Weight

392.5

Purity

≥98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years