dihydro-difluoro Prostaglandin D2

DESCRIPTION

Synonyms

• 13,14-dihydro-16,16-difluoro PGD2

Prostaglandin D2 (PGD2) plays important roles in vascular smooth muscle relaxation, the inhibition of platelet aggregation, and anaphylaxis. 13,14-dihydro-16,16-difluoro PGD2 is an analog of PGD2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.1 Importantly, 13,14-dihydro PGE1has activity that is comparable to that of PGE1, suggesting that this analog of PGD2 could be biologically active.2,3

TECHNICAL INFORMATION

Formal Name

9a,15S-dihydroxy-11-oxo-16,16-difluoro-prosta-5Z-en-1-oic acid

Synonyms

• 13,14-dihydro-16,16-difluoro PGD2

Molecular Formula

C20H32F2O5

Formula Weight

390.5

Purity

≥95%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Stability

≥ 1 year