dihydro Prostaglandin E1

DESCRIPTION

Synonyms

• PGE0
• 13,14-dihydro PGE1

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound.1,2 It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively.3 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 (Item No. 13010) which has an IC50 value of 40 nM.4 Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.5

TECHNICAL INFORMATION

Formal Name

9-oxo-11α,15S-dihydroxy-prostan-1-oic acid

CAS Number

19313-28-1

Synonyms

• PGE0
• 13,14-dihydro PGE1

Molecular Formula

C20H36O5

Formula Weight

356.5

Purity

≥98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Stability

≥ 1 year