GW 1929

Peroxisome proliferator-activated receptor (PPAR) ÃŽ³ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism.1 The best known class of PPAR ³ ligands are the thiazolidinediones, including troglitazone (Item No. 71750) and  (Item No. 71740).2 GW 1929 is a non-thiazolidinedione activator of PPARÃŽ³ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes.3 It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes.3,4 Both in vitro and in vivo effects of GW 1929 on PPARÃŽ³ greatly exceed those produced by troglitazone.3,4 In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.5

TECHNICAL INFORMATION

Formal Name

N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine

CAS Number

196808-24-9

Molecular Formula

C30H29N3O4

Formula Weight

495.6

Purity: 98%

Formulation: A crystalline solid

SHIPPING & STORAGE

Shipping: Room temperature in continental US; may vary elsewhere

Stability:  2 years