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IWR-1-endo

IWR-1-endo
IWR-1-endo
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Product Code : SRGCC52
Brand Name : S.R GROP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1 Pack/Packs
  • Price Range
  • 5400.00 - 43200.00 INR
  • Price
  • 5400-43200 INR
Product Specifications
  • Ph Level
  • REFER C.O.A MSDS
  • Molecular Formula
  • C25H19N3O3
  • Density
  • REFER C.O.A MSDS
  • Taste
  • Bitter
  • Shelf Life
  • 24 Months
  • Molecular Weight
  • 409.4 Kilograms (kg)
  • HS Code
  • 3821
  • Appearance
  • POWDER
  • Boiling point
  • REFER C.O.A MSDS
  • Shape
  • Crystal
  • Smell
  • Stimulus
  • Structural Formula
  • C25H19N3O3
  • Physical Form
  • Solid
  • Other Names
  • 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-benzamide
  • Usage
  • R&D FORMULATION
  • Melting Point
  • REFER C.O.A MSDS
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 1127442-82-3
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.4 It inhibits, at 10 μM, Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and GSK3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK3β.4 The IWR compound does not change the de novo synthesis of Axin2, alter the affinity of Axin2 for β-catenin, or inhibit the proteasome. It has a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes.5 In in vivo tests, IWR-1-endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM.5 The IWR-1-exo diastereomer exhibits much less activity against the Wnt/β-catenin pathway and has been used as a control.4

TECHNICAL INFORMATION

Formal Name

4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-benzamide

CAS Number

1127442-82-3

Molecular Formula

C25H19N3O3

Formula Weight

409.4

Purity

≥98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years


Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 5MG 10MG 25MG 50MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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