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Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.1Â It inhibits K+Â and H+Â accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 ÃÂµM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 ÃÂµM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.2Â It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.3,4Â Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment ofÂ H. pyloriÂ infections and duodenal ulcer disease.
A crystalline solid
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Room temperatureÂ in continental US; may vary elsewhere
Ã¢ÂÂ¥ 2 years