LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent.1,2 (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer.2 When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation.3 Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.
A crystalline solid
SHIPPING & STORAGE
Room temperature in continental US; may vary elsewhere
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