DESCRIPTION
Synonyms
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent.1,2 (R)-LSF is the biologically active isomer of LSF.1,2 It is a potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 M) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock.3 (R)-LSF suppresses the production of the proinflammatory cytokine IFN-, inhibits interleukin 12-mediated STAT-4 activation, and enhances glucose-stimulated -cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.4,1
TECHNICAL INFORMATION
SHIPPING & STORAGE
Storage -20C
Shipping:Room temperature in continental US; may vary elsewhere
SR GROUP
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