O-Arachidonoyl Ethanolamine

DESCRIPTION

Synonyms

• O-AEA
• Arachidonic Acid-(2-aminoethyl)-ester
• Virodhamine

Arachidonoyl ethanolamide (AEA) was the first endogenous  to be isolated and characterized as an agonist acting on the same receptors (CB1and CB2) as tetrahydrocannabinols (THC).1,2 Since that time, a number of related  have been isolated, most notably 2-arachidonoyl glycerol (2-AG).3 O-Arachidonoyl ethanolamine hydrochloride (O-AEA) is a recently isolated constituent of human and rat brain wherein the ethanolamine moiety is attached backwards as an ester instead of an amide, as in AEA.1,2,4 O-AEA has mixed agonist/antagonist activity at the CB1receptor and does not appear to be the native endogenous  agonist at this receptor. This is in keeping with other observations that 2-AG is the primary endogenous CB1 receptor ligand.5

TECHNICAL INFORMATION

• Formal Name:5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-aminoethyl ester, monohydrochloride
• CAS Number:443129-35-9

Synonyms

• O-AEA
• Arachidonic Acid-(2-aminoethyl)-ester
• Virodhamine
•  Molecular Formula:C22H37NO2HCl
• Formula Weight:384.0
• Purity:98%
• Formulation:A neat oil
• SHIPPING & STORAGE
• Storage:-80‚°C
• Shipping:Dry ice in continental US; may vary elsewhere
• Stability: 6 months