OU749 Laboratory Chemical

DESCRIPTION

ÃŽ³-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism.1 Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease.1 OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 ÃŽ¼M.2 It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.2

TECHNICAL INFORMATION

Formal Name

N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide

CAS Number

519170-13-9

Molecular Formula

C16H15N3O3S2

Formula Weight

361.4

Purity

≥95%

Formulation

A crystalline solid

SHIPPING & STORAGE

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years