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PP242

PP242
PP242
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Product Code : SRGCC62
Brand Name : S.R GROUP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price Range
  • 2500.00 - 23800.00 INR
  • Price
  • 2500-23800 INR
Product Specifications
  • Shape
  • Crystal
  • Taste
  • Bitter
  • Physical Form
  • Solid
  • Other Names
  • 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol
  • Usage
  • R&D FORMULATION
  • Appearance
  • POWDER
  • Molecular Formula
  • C16H16N6O
  • Structural Formula
  • C16H16N6O
  • Density
  • REFER C.O.A MSDS
  • Smell
  • Stimulus
  • HS Code
  • 3821
  • Ph Level
  • REFER C.O.A MSDS
  • Melting Point
  • REFER C.O.A MSDS
  • Boiling point
  • REFER C.O.A MSDS
  • Shelf Life
  • 24 Months
  • Molecular Weight
  • 308.3 Kilograms (kg)
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 1092351-67-1
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 95%
  • Color
  • WHITE
Product Description

DESCRIPTION

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin) and regulate different pathways. PP242 is an inhibitor of the active site of mTOR kinase in both mTORC1 and mTORC2 (IC50 = 8 nM).1,2 It less effectively inhibits PKCα, PI3-kinase subunit p110γ, JAK2, PKCβI, and PKCβII (IC50 = 49, 102, 110, 198, and 185, respectively).2,3 PP242 has been shown to cause the death of certain human and murine leukemia cells more potently than rapamycin and, in vivo, delays leukemia onset and augments the effects of tyrosine kinase inhibitors in suppressing leukemic expansion and extending survival.4

TECHNICAL INFORMATION

Formal Name

2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol

CAS Number

1092351-67-1

Molecular Formula

C16H16N6O

Formula Weight

308.3

Purity

≥95%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years


Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Months
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 1MG 5MG 10MG 25MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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