Synonyms
- Celastrol methyl ester
- NSC 99281
Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous 2-arachidonoyl glycerol (2-AG), terminating its capacity to activate receptors. Pristimerin is a naturally occurring terpenoid that potently inhibits MAGL (IC50 = 93 nM).1 Its actions are rapid, reversible, and noncompetitive.1 Pristimerin (1 âµM) significantly increases 2-AG levels in isolated rat neurons, indicating that it inhibits endogenous MAGL in cultured cells.1 Moreover, it does not increase levels of palmitoyl ethanolamide, suggesting that pristimerin does not affect the activity of fatty acid amide hydrolase (FAAH).
TECHNICAL INFORMATION
Formal Name
3-hydroxy-9 ²,13 ±-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester
CAS Number
1258-84-0
Synonyms
- Celastrol methyl ester
- NSC 99281
Molecular Formula: C30H40O4
Formula Weight: 464.6
Purity: 98%
Formulation: A crystalline solid
SHIPPING & STORAGE
Storage: -20 °C
Shipping: Room temperature in continental US; may vary elsewhere
Stability: 2 years