S32826 Chemical

DESCRIPTION

Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin ÃŽ² with an IC50 of 8.8 nM.1 It shows similar effectiveness against the three known autotaxin isoforms (ÃŽ±, ÃŽ², and ÃŽ³). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 ÃŽ¼M) and phosphatase 1B (IC50= 15 ÃŽ¼M).1 S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 ÃŽ¼M.1

TECHNICAL INFORMATION

Formal Name

P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-phosphonic acid

CAS Number

1096770-84-1

Molecular Formula

C21H36NO4P

Formula Weight

397.5

Purity

≥98%

Formulation

A crystalline solid

ÃŽ»max

250 nm

SHIPPING & STORAGE

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years