DESCRIPTION
Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin with an IC50 of 8.8 nM.1 It shows similar effectiveness against the three known autotaxin isoforms (, , and ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 M) and phosphatase 1B (IC50= 15 M).1 S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 M.1
TECHNICAL INFORMATION
Formal Name
P-[[4-[(1-oxo
CAS Number
1096770-84-1
Molecular Formula
C21H36NO4P
Formula Weight
397.5
Purity
98%
Formulation
A crystalline solid
max
250 nm
SHIPPING & STORAGE
-20C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
2 years
SR GROUP
All Rights Reserved.(Terms of Use) Developed and Managed by Infocom Network Private Limited. |