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Tafamidis Chemical

Tafamidis Chemical

26500 INR

Product Details:

  • Molecular Formula C14H7Cl2NO3
  • Ph Level REFER C.O.A MSDS
  • Physical Form Solid
  • Shape Crystal
  • Usage R&D FORMULATION
  • Other Names 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid
  • Appearance SOLID
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Tafamidis Chemical Price And Quantity

  • 26500 INR
  • 26500.00 - 26500.00 INR
  • 1 Pack

Tafamidis Chemical Product Specifications

  • Solid
  • C14H7Cl2NO3
  • Crystal
  • 98%
  • REFER C.O.A MSDS
  • TETRA HYDROXI STEAROL
  • C14H7Cl2NO3
  • REFER C.O.A MSDS
  • High Purity
  • WHITE
  • 3821
  • REFER C.O.A MSDS
  • 308.1 Kilograms (kg)
  • 24 Months
  • Other
  • 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid
  • 594839-88-0
  • Fragrant
  • R&D FORMULATION
  • Bitter
  • SOLID

Tafamidis Chemical Trade Information

  • Cheque Cash Advance (CA) Days after Acceptance (DA)
  • 10 Pack Per Day
  • 10-15 Days
  • Yes
  • Within a certain price range free samples are available
  • 5MG
  • Asia
  • All India

Product Description

DESCRIPTION

Synonyms

  • PF-06291826

Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs.1 It binds to TTR with negative cooperativity (Kd1 = 3 nM; Kd2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s = 2.7-3.2 M) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 M. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.2

TECHNICAL INFORMATION

Formal Name

2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid

CAS Number

594839-88-0

Synonyms

  • PF-06291826

 

Molecular Formula

C14H7Cl2NO3

Formula Weight

308.1

Purity

98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

 

-20C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

2 years

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