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Tafamidis

Tafamidis
Tafamidis
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Product Code : SRGCC31
Brand Name : S.R GROUP CHEMIC ALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price Range
  • 26500.00 - 26500.00 INR
  • Price
  • 26500 INR
Product Specifications
  • Physical Form
  • Solid
  • Shelf Life
  • 24 Months
  • Boiling point
  • REFER C.O.A MSDS
  • Melting Point
  • REFER C.O.A MSDS
  • Shape
  • Crystal
  • Ph Level
  • REFER C.O.A MSDS
  • Molecular Weight
  • 308.1 Kilograms (kg)
  • Structural Formula
  • C14H7Cl2NO3
  • HS Code
  • 3821
  • Appearance
  • SOLID
  • Density
  • REFER C.O.A MSDS
  • Usage
  • R&D FORMULATION
  • Molecular Formula
  • C14H7Cl2NO3
  • Other Names
  • 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid
  • Taste
  • Bitter
  • Smell
  • Fragrant
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 594839-88-0
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

Synonyms

  • PF-06291826

Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs.1 It binds to TTR with negative cooperativity (Kd1 = 3 nM; Kd2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s = 2.7-3.2 μM) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 μM. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.2

TECHNICAL INFORMATION

Formal Name

2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid

CAS Number

594839-88-0

Synonyms

  • PF-06291826

Molecular Formula

C14H7Cl2NO3

Formula Weight

308.1

Purity

≥98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years

Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 5MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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