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UNC0224

UNC0224
UNC0224
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Product Code : SRGCC71
Brand Name : S.R GROUP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price
  • 3800-77000 INR
  • Price Range
  • 3800.00 - 77000.00 INR
Product Specifications
  • Other Names
  • 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
  • Shelf Life
  • 24 Months
  • Ph Level
  • REFER C.O.A MSDS
  • Molecular Weight
  • 485.7 Kilograms (kg)
  • Density
  • REFER C.O.A MSDS
  • Usage
  • R&D FORMULATION
  • Shape
  • Crystal
  • Structural Formula
  • C26H43N7O2
  • Smell
  • Stimulus
  • Melting Point
  • REFER C.O.A MSDS
  • Appearance
  • POWDER
  • Taste
  • Bitter
  • Molecular Formula
  • C26H43N7O2
  • Physical Form
  • Solid
  • HS Code
  • 3821
  • Boiling point
  • REFER C.O.A MSDS
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 1197196-48-7
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.1,2,3 UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM.4 Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase).4

TECHNICAL INFORMATION

Formal Name

7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine

CAS Number

1197196-48-7

Molecular Formula

C26H43N7O2

Formula Weight

485.7

Purity

≥98%

Formulation

A crystalline solid

λmax

251, 346 nm

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years


Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 1MG 5MG 10MG 50MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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