call-us
Home » Products » LABORATORY CHEMICAL » Wortmannin-Rapamycin Conjugate

Wortmannin-Rapamycin Conjugate

Wortmannin-Rapamycin Conjugate
Wortmannin-Rapamycin Conjugate
Send Inquiry
Product Code : SRGCC44
Brand Name : S.R GROUP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price Range
  • 12400.00 - 99200.00 INR
  • Price
  • 12400-99200 INR
Product Specifications
  • Molecular Weight
  • 1598.9 Kilograms (kg)
  • Appearance
  • POWDER
  • Smell
  • Stimulus
  • Physical Form
  • Powder
  • Shelf Life
  • 24 Months
  • HS Code
  • 3821
  • Shape
  • Crystal
  • Other Names
  • 1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate
  • Taste
  • Bitter
  • Molecular Formula
  • C88H131N3O23
  • Usage
  • R&D FORMULATION
  • Boiling point
  • REFER C.O.A MSDS
  • Structural Formula
  • C88H131N3O23
  • Ph Level
  • REFER C.O.A MSDS
  • Melting Point
  • REFER C.O.A MSDS
  • Density
  • REFER C.O.A MSDS
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 1067892-47-0
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1.1,2 Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker.3 Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone.3 Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.3

TECHNICAL INFORMATION

Formal Name

1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate

CAS Number

1067892-47-0

Molecular Formula

C88H131N3O23

Formula Weight

1598.9

Purity

≥98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years


Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 500 µg 1 MG 5MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

SR GROUP
X


SR GROUP All Rights Reserved.(Terms of Use)
Developed and Managed by Infocom Network Ltd.