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Wortmannin-Rapamycin Conjugate

Wortmannin-Rapamycin Conjugate

12400-99200 INR

Product Details:

  • Molecular Formula C88H131N3O23
  • Melting Point REFER C.O.A MSDS
  • Shape Crystal
  • Ph Level REFER C.O.A MSDS
  • Molecular Weight 1598.9 Kilograms (kg)
  • Taste Bitter
  • Other Names 1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate
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Wortmannin-Rapamycin Conjugate Price And Quantity

  • 12400.00 - 99200.00 INR
  • 12400-99200 INR
  • 1 Pack

Wortmannin-Rapamycin Conjugate Product Specifications

  • REFER C.O.A MSDS
  • C88H131N3O23
  • Crystal
  • 1598.9 Kilograms (kg)
  • REFER C.O.A MSDS
  • WHITE
  • REFER C.O.A MSDS
  • POWDER
  • 1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate
  • 98%
  • Other
  • TETRA HYDROXI STEAROL
  • Bitter
  • Stimulus
  • R&D FORMULATION
  • 24 Months
  • High Purity
  • Powder
  • 1067892-47-0
  • C88H131N3O23
  • 3821

Wortmannin-Rapamycin Conjugate Trade Information

  • Days after Acceptance (DA) Cheque Cash Advance (CA)
  • 10 Pack Per Day
  • 10-15 Days
  • Yes
  • Within a certain price range free samples are available
  • 500 g 1 MG 5MG
  • Asia
  • All India

Product Description

DESCRIPTION

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1.1,2 Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker.3 Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone.3 Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.3

TECHNICAL INFORMATION

Formal Name

1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate 8-(7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone octanedioate

CAS Number

1067892-47-0

Molecular Formula

C88H131N3O23

Formula Weight

1598.9

Purity

98%

Formulation

A crystalline solid

SHIPPING & STORAGE

Storage

 

-20C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

2 years


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