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YS-121

YS-121
YS-121
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Product Code : SRGCC48
Brand Name : S.R GROUP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price
  • 4300-75300 INR
  • Price Range
  • 4300.00 - 75300.00 INR
Product Specifications
  • Taste
  • Bitter
  • Appearance
  • PODER
  • Smell
  • Stimulus
  • Shape
  • Crystal
  • Ph Level
  • REFER C.O.A MSDS
  • Shelf Life
  • 12 Months
  • Boiling point
  • REFER C.O.A MSDS
  • HS Code
  • 3821
  • Molecular Formula
  • C20H26ClN3O2S
  • Structural Formula
  • C20H26ClN3O2S
  • Other Names
  • 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid
  • Physical Form
  • Other
  • Density
  • REFER C.O.A MSDS
  • Usage
  • R&D FORMULATION
  • Melting Point
  • REFER C.O.A MSDS
  • Molecular Weight
  • 408.0 Kilograms (kg)
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 916482-17-2
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

DESCRIPTION

Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM)1 and 5-LO (IC50 = 4.1 μM).2 It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy.3 YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.1

TECHNICAL INFORMATION

Formal Name

2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid

CAS Number

916482-17-2

Molecular Formula

C20H26ClN3O2S

Formula Weight

408.0

Purity

≥98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 1 year


Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Packaging Details
  • 1MG 5MG 10MG 25MG
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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