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YS-121

YS-121

4300-75300 INR

Product Details:

  • Taste Bitter
  • Melting Point REFER C.O.A MSDS
  • Molecular Weight 408.0 Kilograms (kg)
  • Boiling point REFER C.O.A MSDS
  • Density REFER C.O.A MSDS
  • Shelf Life 12 Months
  • Ph Level REFER C.O.A MSDS
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YS-121 Price And Quantity

  • 4300-75300 INR
  • 1 Pack
  • 4300.00 - 75300.00 INR

YS-121 Product Specifications

  • 916482-17-2
  • REFER C.O.A MSDS
  • REFER C.O.A MSDS
  • 98%
  • 12 Months
  • REFER C.O.A MSDS
  • 408.0 Kilograms (kg)
  • R&D FORMULATION
  • Stimulus
  • 3821
  • Other
  • C20H26ClN3O2S
  • 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid
  • WHITE
  • C20H26ClN3O2S
  • PODER
  • High Purity
  • Other
  • REFER C.O.A MSDS
  • Bitter
  • TETRA HYDROXI STEAROL
  • Crystal

YS-121 Trade Information

  • Days after Acceptance (DA) Cheque Cash Advance (CA)
  • 10 Pack Per Day
  • 10-15 Days
  • Yes
  • 1MG 5MG 10MG 25MG
  • Asia
  • All India

Product Description

DESCRIPTION

Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM)1 and 5-LO (IC50 = 4.1 μM).2 It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy.3 YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.1

TECHNICAL INFORMATION

Formal Name

2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid

CAS Number

916482-17-2

Molecular Formula

C20H26ClN3O2S

Formula Weight

408.0

Purity

≥98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 1 year


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