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ZK118182 isopropyl ester

ZK118182 isopropyl ester
ZK118182 isopropyl ester
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Product Code : SRGCC41
Brand Name : S.R GROUP CHEMICALS
Price And Quantity
  • Minimum Order Quantity
  • 1
  • Unit of Measure
  • Pack/Packs
  • Price
  • 16900-76100 INR
  • Price Range
  • 16900.00 - 76100.00 INR
Product Specifications
  • HS Code
  • 3821
  • Appearance
  • POWDER
  • Taste
  • Bitter
  • Molecular Formula
  • C23H37ClO5
  • Smell
  • Stimulus
  • Shelf Life
  • 12 Months
  • Ph Level
  • REFER C.O.A MSDS
  • Usage
  • R&D FORMULATION
  • Shape
  • Crystal
  • Density
  • Kilogram per cubic meter (kg/m3)
  • Other Names
  • [[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester
  • Physical Form
  • Powder
  • Structural Formula
  • C23H37ClO5
  • Molecular Weight
  • 429.0 Kilograms (kg)
  • Boiling point
  • REFER C.O.A MSDS
  • Melting Point
  • REFER C.O.A MSDS
  • Classification
  • High Purity
  • Chemical Name
  • Other
  • CAS No
  • 154927-31-8
  • Type
  • TETRA HYDROXI STEAROL
  • Purity(%)
  • 98%
  • Color
  • WHITE
Product Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2 and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki= 74 nM).1 ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03g , ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.2

TECHNICAL INFORMATION

Formal Name

[[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester

CAS Number

154927-31-8

Molecular Formula

C23H37ClO5

Formula Weight

429.0

Purity

98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

Storage

 

-20oC

Shipping

Room temperature in continental US; may vary elsewhere

Stability

1 year

Trade Information
  • Payment Terms
  • Days after Acceptance (DA), Cheque, Cash Advance (CA)
  • Supply Ability
  • 10 Per Day
  • Delivery Time
  • 10-15 Days
  • Sample Available
  • Yes
  • Sample Policy
  • Within a certain price range free samples are available
  • Packaging Details
  • 100 µg 500 µg
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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