ZK118182 isopropyl ester

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Product Code : SRGCC41

Brand Name : S.R GROUP CHEMICALS

Price And Quantity

Minimum Order Quantity
1 Pack
Price Range
16900.00 - 76100.00 INR

Price
16900-76100 INR

Product Specifications

Melting Point
REFER C.O.A MSDS
Shape
Crystal

Molecular Formula
C23H37ClO5
Ph Level
REFER C.O.A MSDS

Other Names
[[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester
Boiling point
REFER C.O.A MSDS

Molecular Weight
429.0 Kilograms (kg)
Taste
Bitter

Appearance
POWDER
Structural Formula
C23H37ClO5

Density
Kilogram per cubic meter (kg/m3)
Usage
R&D FORMULATION

Physical Form
Powder
Shelf Life
12 Months

HS Code
3821
Smell
Stimulus

Classification
High Purity
Chemical Name
Other

CAS No
154927-31-8
Type
TETRA HYDROXI STEAROL

Purity(%)
98%
Color
WHITE

Product Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2 and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki= 74 nM).1 ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03g , ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.2

TECHNICAL INFORMATION

Formal Name

[[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester

CAS Number

154927-31-8

Molecular Formula

C23H37ClO5

Formula Weight

429.0

Purity

98%

Formulation

A solution in methyl acetate

SHIPPING & STORAGE

Storage

-20^oC

Shipping

Room temperature in continental US; may vary elsewhere

Stability

1 year

Trade Information