CPI-360

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CPI-360

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Product Code : 1802175-06-9

Product Description

DESCRIPTION

CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively.1 It decreases cellular levels of H3K27me3 and H3K27me2 (EC50s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of non-Hodgkin’s lymphoma (NHL) cell lines.1 Twice daily, subcutaneous administration of 200 mg/kg of CPI-360 reduced tumor growth of KARPAS-422 xenografts in mice.1

TECHNICAL INFORMATION

Formal Name : N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-indole-3-carboxamide
CAS Number : 1802175-06-9
Molecular Formula : C25H31N3O4
Formula Weight : 437.5
Purity : ≥98%
Formulation : A crystalline solid
λmax : 212, 292 nm
SMILES : CC(N1)=CC(OC)=C(CNC(C2=C(C)N([C@H](C)C3CCOCC3)C4=C2C=CC=C4)=O)C1=O
InChI Code : 1S/C25H31N3O4/c1-15-13-22(31-4)20(24(29)27-15)14-26-25(30)23-17(3)28(21-8-6-5-7-19(21)23)16(2)18-9-11-32-12-10-18/h5-8,13,16,18H,9-12,14H2,1-4H3,(H,26,30)(H,27,29)/t16-/m1/s1
InChI Key : PFPSFENQCNMITC-MRXNPFEDSA-N

WARNING - This product is not for human or veterinary use.

SHIPPING & STORAGE

Storage : -20°C
Shipping : Wet ice in continental US; may vary elsewhere
Stability : As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly