
DESCRIPTION
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2± and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an EC50 value of 0.80 µM in an in vitro functional assay.1 Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily.1
TECHNICAL INFORMATION
Formal Name
2-[[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(3R)-3-cyclohexyl-3-hydroxypropyl]-3-hydroxycyclopentyl]-2-buten-1-yl]oxy]-1-methylethyl ester, acetic acid
CAS Number:170291-06-2
Molecular Formula:C23H39ClO5
Formula Weight:431.0
Purity: 97%
Formulation:A solution in methyl acetate
SHIPPING & STORAGE
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability:1 year
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